The team responsible for Ghost World—director Terry Zwigoff, screenwriter/comic book artist Daniel Clowes, and John Malkovich’s production company—reunites for this bitter satirical comedy. An ambitious and virginal young artist (Max Minghella) arrives at art school in search of sex and fame, but the careerism he encounters causes him to despair and betray his talent, especially when the model he loves (Sophia Myles) goes after one of his classmates. It’s a fascinating and provocative muddle: social satire, self-hatred, misanthropy, and misogyny become hard to disentangle as a subplot involving a serial killer comes to the fore. With Malkovich, Matt Keeslar, Jim Broadbent, Steve Buscemi, and Anjelica Huston. R, 102 min.