Despite some artful visuals and harrowing testimony, this 2012 advocacy documentary suffers from a lack of focus. The title refers to prescribing a medication to treat conditions other than that for which it was designed, but in their zeal to expose corruption, directors Michael Palmieri and Donal Mosher go off topic for a general indictment of Big Pharma. Two impoverished loners are weak examples of industrial abuse because entering clinical trials is their livelihood; a war veteran claims he needs talk therapy, not drugs; and a Rochester, Minnesota, sequence exists just because the Mayo Clinic is the state’s largest private employer. Only a pharmaceuticals rep turned whistle-blower offers real insight, explaining how a product comes to be “in demand.”