Melissa McCarthy stars as a midwestern loudmouth who, fired from her job at a burger joint and furious that her husband is having an affair, skips town with her wily, pill-popping grandmother (Susan Sarandon). Their sights are set on Niagara Falls, but a booze-filled run-in with the police strands them in Louisville. Like a classic road comedy, this tends to drift from scene to scene rather than adhere to a strict plot; the movie revolves mostly around McCarthy, hilarious in her best performance to date. She cowrote the script with her husband, Ben Falcone, providing her character with a nuance absent from her other starring roles; she shows a more dramatic side, and not every joke is predicated on her weight. Falcone directed; with Kathy Bates and Mark Duplass.